Activity Dynamics and Signal Representation in a Striatal Network Model with Distance-Dependent Connectivity
نویسندگان
چکیده
منابع مشابه
Activity Dynamics and Signal Representation in a Striatal Network Model with Distance-Dependent Connectivity
The striatum is the main input nucleus of the basal ganglia. Characterizing striatal activity dynamics is crucial to understanding mechanisms underlying action selection, initiation, and execution. Here, we studied the effects of spatial network connectivity on the spatiotemporal structure of striatal activity. We show that a striatal network with nonmonotonically changing distance-dependent co...
متن کاملActivity Dynamics and Signal Representation in Striatal Network Model with Distance-dependent Connectivity
Striatum is predominantly inhibitory and the main input nucleus of the basal ganglia. A functional characterization of its activity dynamics is crucial for understanding the mechanisms underlying phenomenon such as action selection and initiation. Here, we investigated the effects of the spatial connectivity structure on the emergence and maintenance of localized bumps of activity in large-scal...
متن کاملHeterogeneous network with distance dependent connectivity
We investigate a network model based on an infinite regular square lattice embedded in the Euclidean plane where the node connection probability is given by the geometrical distance of nodes. We show that the degree distribution in the basic model is sharply peaked around its mean value. Since the model was originally developed to mimic the social network of acquaintances, to broaden the degree...
متن کاملInput Dependent Cell Assembly Dynamics in a Model of the Striatal Medium Spiny Neuron Network
The striatal medium spiny neuron (MSN) network is sparsely connected with fairly weak GABAergic collaterals receiving an excitatory glutamatergic cortical projection. Peri-stimulus time histograms (PSTH) of MSN population response investigated in various experimental studies display strong firing rate modulations distributed throughout behavioral task epochs. In previous work we have shown by n...
متن کاملChanges in striatal activity and functional connectivity in a mouse model of Huntington's disease
Hereditary Huntington's disease (HD) is associated with progressive motor, cognitive and psychiatric symptoms. A primary consequence of the HD mutation is the preferential loss of medium spiny projection cells with relative sparing of local interneurons in the striatum. In addition, among GABAergic striatal projection cells, indirect pathway cells expressing D2 dopamine receptors are lost earli...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eneuro
سال: 2017
ISSN: 2373-2822
DOI: 10.1523/eneuro.0348-16.2017